相互作用
Calcium / magnesium / potassium / sodium oxybates + Cyclizine
重症度: 重大
Calcium / magnesium / potassium / sodium oxybates and Cyclizine: major interaction.
最終更新日
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概要
Oxybate salts cause marked CNS and respiratory depression, and cyclizine is a sedating antihistamine. Combined use can result in profound sedation, respiratory depression, coma and death.
この相互作用をわかりやすく説明すると
Calcium / magnesium / potassium / sodium oxybates and Cyclizine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Additive CNS and respiratory depression through pharmacodynamic synergism.
対処法
Avoid concurrent use where alternatives exist; if unavoidable, use the lowest effective doses and monitor closely for sedation and respiratory depression.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Calcium / magnesium / potassium / sodium oxybatesとCyclizineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Cyclizineのその他の相互作用
よくある質問
Can I take Calcium / magnesium / potassium / sodium oxybates with Cyclizine?
MediHelp rates the interaction as major. Calcium / magnesium / potassium / sodium oxybates and Cyclizine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oxybate salts cause marked CNS and respiratory depression, and cyclizine is a sedating antihistamine. Combined use can result in profound sedation, respiratory depression, coma and death.
How serious is the interaction between Calcium / magnesium / potassium / sodium oxybates and Cyclizine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where alternatives exist; if unavoidable, use the lowest effective doses and monitor closely for sedation and respiratory depression.
What other medicines interact with Cyclizine?
MediHelp also lists interactions of Cyclizine with, for example, Henbane, Sodium oxybate, Abobotulinumtoxina. The full list is on the Cyclizine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
