相互作用
Cyclizine + Sodium oxybate
重症度: 重大
Cyclizine and Sodium oxybate: major interaction.
最終更新日
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概要
Sodium oxybate strongly depresses the CNS and breathing, and cyclizine adds sedation. The combination can lead to profound sedation, respiratory depression, coma and death.
この相互作用をわかりやすく説明すると
Cyclizine and Sodium oxybate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclizine belongs to Respiratory; Sodium oxybate belongs to Central Nervous System.
なぜ起こるのか
Additive CNS and respiratory depression through pharmacodynamic synergism.
対処法
Avoid the combination if possible; if not, use minimal doses and duration and monitor closely for sedation and respiratory depression.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CyclizineとSodium oxybateの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Cyclizineのその他の相互作用
Sodium oxybateのその他の相互作用
よくある質問
Can I take Cyclizine with Sodium oxybate?
MediHelp rates the interaction as major. Cyclizine and Sodium oxybate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sodium oxybate strongly depresses the CNS and breathing, and cyclizine adds sedation. The combination can lead to profound sedation, respiratory depression, coma and death.
How serious is the interaction between Cyclizine and Sodium oxybate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; if not, use minimal doses and duration and monitor closely for sedation and respiratory depression.
What other medicines interact with Cyclizine?
MediHelp also lists interactions of Cyclizine with, for example, Calcium / magnesium / potassium / sodium oxybates, Henbane, Abobotulinumtoxina. The full list is on the Cyclizine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
