相互作用
Calcium / magnesium / potassium / sodium oxybates + Methadone
重症度: 併用禁忌
Calcium / magnesium / potassium / sodium oxybates and Methadone: contraindicated interaction.
最終更新日
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概要
Oxybates and methadone both depress the CNS, and together can cause profound sedation, respiratory depression, coma and death. Oxybate labeling restricts use with opioids.
この相互作用をわかりやすく説明すると
Calcium / magnesium / potassium / sodium oxybates and Methadone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
なぜ起こるのか
Additive CNS and respiratory depression through opioid and GABA-B/GHB receptor activity.
対処法
Avoid the combination and choose alternative therapy. If it is truly unavoidable, minimize doses and duration and monitor respiratory function and sedation continuously.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Calcium / magnesium / potassium / sodium oxybatesとMethadoneの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Methadoneのその他の相互作用
よくある質問
Can I take Calcium / magnesium / potassium / sodium oxybates with Methadone?
MediHelp rates the interaction as contraindicated. Calcium / magnesium / potassium / sodium oxybates and Methadone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Oxybates and methadone both depress the CNS, and together can cause profound sedation, respiratory depression, coma and death. Oxybate labeling restricts use with opioids.
How serious is the interaction between Calcium / magnesium / potassium / sodium oxybates and Methadone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose alternative therapy. If it is truly unavoidable, minimize doses and duration and monitor respiratory function and sedation continuously.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Droperidol, Ibutilide. The full list is on the Methadone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
