相互作用
Levoketoconazole + Methadone
重症度: 併用禁忌
Levoketoconazole and Methadone: contraindicated interaction.
最終更新日
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概要
Levoketoconazole strongly inhibits CYP3A4 and prolongs the QT interval, and methadone shares both features of risk. The combination can increase methadone concentrations and the risk of torsades de pointes and respiratory depression.
この相互作用をわかりやすく説明すると
Levoketoconazole and Methadone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Levoketoconazole belongs to Endocrine; Methadone belongs to Musculoskeletal.
なぜ起こるのか
CYP3A4 inhibition raises methadone exposure, with additive QT prolongation.
対処法
Do not use together; consider an alternative treatment for hypercortisolism or opioid therapy. Correct electrolytes and monitor ECG if the combination cannot be avoided.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、LevoketoconazoleとMethadoneの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Methadoneのその他の相互作用
Levoketoconazoleのその他の相互作用
よくある質問
Can I take Levoketoconazole with Methadone?
MediHelp rates the interaction as contraindicated. Levoketoconazole and Methadone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Levoketoconazole strongly inhibits CYP3A4 and prolongs the QT interval, and methadone shares both features of risk. The combination can increase methadone concentrations and the risk of torsades de pointes and respiratory depression.
How serious is the interaction between Levoketoconazole and Methadone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; consider an alternative treatment for hypercortisolism or opioid therapy. Correct electrolytes and monitor ECG if the combination cannot be avoided.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
