相互作用
Lefamulin + Methadone
重症度: 併用禁忌
Lefamulin and Methadone: contraindicated interaction.
最終更新日
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概要
Lefamulin is a CYP3A4 inhibitor and itself prolongs the QT interval, and methadone is a CYP3A4 substrate with QT risk. The combination can raise methadone levels and increase the risk of torsades de pointes.
この相互作用をわかりやすく説明すると
Lefamulin and Methadone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Lefamulin belongs to Anti Bacterial; Methadone belongs to Musculoskeletal.
なぜ起こるのか
CYP3A4 inhibition by lefamulin increases methadone exposure, with additive QT prolongation.
対処法
Avoid lefamulin with methadone, particularly oral lefamulin, and choose an alternative antibiotic. If unavoidable, monitor ECG and for opioid toxicity.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、LefamulinとMethadoneの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Methadoneのその他の相互作用
Lefamulinのその他の相互作用
よくある質問
Can I take Lefamulin with Methadone?
MediHelp rates the interaction as contraindicated. Lefamulin and Methadone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lefamulin is a CYP3A4 inhibitor and itself prolongs the QT interval, and methadone is a CYP3A4 substrate with QT risk. The combination can raise methadone levels and increase the risk of torsades de pointes.
How serious is the interaction between Lefamulin and Methadone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid lefamulin with methadone, particularly oral lefamulin, and choose an alternative antibiotic. If unavoidable, monitor ECG and for opioid toxicity.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
