相互作用
Candesartan-hydrochlorothiazide + Ethacrynic acid
重症度: 重大
Candesartan-hydrochlorothiazide and Ethacrynic acid: major interaction.
最終更新日
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概要
Ethacrynic acid is a potent loop diuretic and combining it with a thiazide can cause marked diuresis, volume depletion, hypotension, hypokalemia and hyponatremia. Candesartan may add to hypotension and renal impairment in volume-depleted patients.
この相互作用をわかりやすく説明すると
Candesartan-hydrochlorothiazide and Ethacrynic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Ethacrynic acid belongs to Cardiovascular.
なぜ起こるのか
Sequential nephron blockade with a loop diuretic and a thiazide produces additive natriuresis and potassium loss.
対処法
Monitor electrolytes, renal function, weight and blood pressure closely, and reduce diuretic doses if volume depletion develops. Replace potassium and magnesium as needed.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Candesartan-hydrochlorothiazideとEthacrynic acidの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Candesartan-hydrochlorothiazideのその他の相互作用
Ethacrynic acidのその他の相互作用
よくある質問
Can I take Candesartan-hydrochlorothiazide with Ethacrynic acid?
MediHelp rates the interaction as major. Candesartan-hydrochlorothiazide and Ethacrynic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ethacrynic acid is a potent loop diuretic and combining it with a thiazide can cause marked diuresis, volume depletion, hypotension, hypokalemia and hyponatremia. Candesartan may add to hypotension and renal impairment in volume-depleted patients.
How serious is the interaction between Candesartan-hydrochlorothiazide and Ethacrynic acid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor electrolytes, renal function, weight and blood pressure closely, and reduce diuretic doses if volume depletion develops. Replace potassium and magnesium as needed.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
