相互作用
Candesartan-hydrochlorothiazide + Sparsentan
重症度: 併用禁忌
Candesartan-hydrochlorothiazide and Sparsentan: contraindicated interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Sparsentan also blocks the angiotensin II receptor, so adding candesartan duplicates this action. This raises the risk of hypotension, syncope, hyperkalemia and acute kidney injury.
この相互作用をわかりやすく説明すると
Candesartan-hydrochlorothiazide and Sparsentan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Sparsentan belongs to Genitourinary.
なぜ起こるのか
Additive pharmacodynamic angiotensin II type 1 receptor blockade.
対処法
Do not combine; stop the ARB before starting sparsentan.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Candesartan-hydrochlorothiazideとSparsentanの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Candesartan-hydrochlorothiazideのその他の相互作用
Sparsentanのその他の相互作用
よくある質問
Can I take Candesartan-hydrochlorothiazide with Sparsentan?
MediHelp rates the interaction as contraindicated. Candesartan-hydrochlorothiazide and Sparsentan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Sparsentan also blocks the angiotensin II receptor, so adding candesartan duplicates this action. This raises the risk of hypotension, syncope, hyperkalemia and acute kidney injury.
How serious is the interaction between Candesartan-hydrochlorothiazide and Sparsentan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; stop the ARB before starting sparsentan.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Acemetacin. The full list is on the Candesartan-hydrochlorothiazide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
