相互作用
Captopril-hydrochlorothiazide + Dofetilide
重症度: 併用禁忌
Captopril-hydrochlorothiazide and Dofetilide: contraindicated interaction.
最終更新日
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概要
Hydrochlorothiazide can raise dofetilide concentrations and may cause hypokalemia or hypomagnesemia, both of which promote QT prolongation. This increases the risk of torsades de pointes and ventricular arrhythmias.
この相互作用をわかりやすく説明すると
Captopril-hydrochlorothiazide and Dofetilide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Dofetilide belongs to Cardiovascular.
なぜ起こるのか
Thiazides reduce renal clearance of dofetilide (inhibiting cationic renal secretion) and cause electrolyte depletion, adding to QT prolongation.
対処法
Avoid per dofetilide labeling; use an alternative antihypertensive or antiarrhythmic and correct potassium and magnesium if dofetilide is essential.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Captopril-hydrochlorothiazideとDofetilideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Captopril-hydrochlorothiazideのその他の相互作用
Dofetilideのその他の相互作用
よくある質問
Can I take Captopril-hydrochlorothiazide with Dofetilide?
MediHelp rates the interaction as contraindicated. Captopril-hydrochlorothiazide and Dofetilide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Hydrochlorothiazide can raise dofetilide concentrations and may cause hypokalemia or hypomagnesemia, both of which promote QT prolongation. This increases the risk of torsades de pointes and ventricular arrhythmias.
How serious is the interaction between Captopril-hydrochlorothiazide and Dofetilide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid per dofetilide labeling; use an alternative antihypertensive or antiarrhythmic and correct potassium and magnesium if dofetilide is essential.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Sacubitril / valsartan, Aceclofenac. The full list is on the Captopril-hydrochlorothiazide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
