相互作用
Carbamazepine + Roflumilast
重症度: 重大
Carbamazepine and Roflumilast: major interaction.
最終更新日
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概要
Carbamazepine is a strong inducer of CYP3A4, CYP2B6, CYP1A2 and P-glycoprotein and accelerates the clearance of roflumilast. The result is lower roflumilast and roflumilast N-oxide exposure and reduced benefit in COPD.
この相互作用をわかりやすく説明すると
Carbamazepine and Roflumilast can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carbamazepine belongs to Central Nervous System; Roflumilast belongs to Respiratory.
なぜ起こるのか
Enzyme induction by carbamazepine increases metabolic clearance of roflumilast
対処法
Avoid where possible by choosing a non-inducing alternative; if unavoidable, monitor clinical response (and drug levels where available) and consider a higher roflumilast dose only per specialist advice.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CarbamazepineとRoflumilastの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Roflumilastのその他の相互作用
Carbamazepineのその他の相互作用
よくある質問
Can I take Carbamazepine with Roflumilast?
MediHelp rates the interaction as major. Carbamazepine and Roflumilast can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbamazepine is a strong inducer of CYP3A4, CYP2B6, CYP1A2 and P-glycoprotein and accelerates the clearance of roflumilast. The result is lower roflumilast and roflumilast N-oxide exposure and reduced benefit in COPD.
How serious is the interaction between Carbamazepine and Roflumilast?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid where possible by choosing a non-inducing alternative; if unavoidable, monitor clinical response (and drug levels where available) and consider a higher roflumilast dose only per specialist advice.
What other medicines interact with Roflumilast?
MediHelp also lists interactions of Roflumilast with, for example, Apalutamide, Efavirenz, Enzalutamide. The full list is on the Roflumilast page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
