相互作用
Fosphenytoin + Roflumilast
重症度: 重大
Fosphenytoin and Roflumilast: major interaction.
最終更新日
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概要
Fosphenytoin is converted to phenytoin, which induces CYP3A4 and CYP1A2 and substantially reduces roflumilast exposure. Therapeutic effect may be lost.
この相互作用をわかりやすく説明すると
Fosphenytoin and Roflumilast can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fosphenytoin belongs to Central Nervous System; Roflumilast belongs to Respiratory.
なぜ起こるのか
Phenytoin induces CYP3A4 and CYP1A2, increasing roflumilast clearance.
対処法
Avoid the combination where possible, as the label advises against strong inducers. If both are required, monitor COPD control closely and consider an alternative to roflumilast.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、FosphenytoinとRoflumilastの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Roflumilastのその他の相互作用
Fosphenytoinのその他の相互作用
よくある質問
Can I take Fosphenytoin with Roflumilast?
MediHelp rates the interaction as major. Fosphenytoin and Roflumilast can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fosphenytoin is converted to phenytoin, which induces CYP3A4 and CYP1A2 and substantially reduces roflumilast exposure. Therapeutic effect may be lost.
How serious is the interaction between Fosphenytoin and Roflumilast?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, as the label advises against strong inducers. If both are required, monitor COPD control closely and consider an alternative to roflumilast.
What other medicines interact with Roflumilast?
MediHelp also lists interactions of Roflumilast with, for example, Apalutamide, Carbamazepine, Efavirenz. The full list is on the Roflumilast page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
