相互作用
Carboplatin + Dexamethasone-tobramycin
重症度: 重大
Carboplatin and Dexamethasone-tobramycin: major interaction.
最終更新日
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概要
Carboplatin and tobramycin are both nephrotoxic and ototoxic, and combining them increases the risk of kidney injury and hearing loss. Risk is higher with renal impairment, dehydration or high cumulative doses.
この相互作用をわかりやすく説明すると
Carboplatin and Dexamethasone-tobramycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carboplatin belongs to Oncology; Dexamethasone-tobramycin belongs to Anti Bacterial.
なぜ起こるのか
Additive nephrotoxic and ototoxic effects of platinum agents and aminoglycosides.
対処法
Avoid combining if an alternative antibiotic exists; otherwise monitor serum creatinine, tobramycin levels and hearing, and ensure adequate hydration.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CarboplatinとDexamethasone-tobramycinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Dexamethasone-tobramycinのその他の相互作用
Carboplatinのその他の相互作用
よくある質問
Can I take Carboplatin with Dexamethasone-tobramycin?
MediHelp rates the interaction as major. Carboplatin and Dexamethasone-tobramycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carboplatin and tobramycin are both nephrotoxic and ototoxic, and combining them increases the risk of kidney injury and hearing loss. Risk is higher with renal impairment, dehydration or high cumulative doses.
How serious is the interaction between Carboplatin and Dexamethasone-tobramycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining if an alternative antibiotic exists; otherwise monitor serum creatinine, tobramycin levels and hearing, and ensure adequate hydration.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Ciprofloxacin, Cisplatin. The full list is on the Dexamethasone-tobramycin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
