相互作用
Ciprofloxacin + Dexamethasone-tobramycin
重症度: 重大
Ciprofloxacin and Dexamethasone-tobramycin: major interaction.
最終更新日
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概要
Fluoroquinolones and systemic corticosteroids together increase the risk of tendinopathy and tendon rupture, especially in older patients. Risk is greatest with systemic corticosteroid exposure.
この相互作用をわかりやすく説明すると
Ciprofloxacin and Dexamethasone-tobramycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ciprofloxacin belongs to Anti Bacterial; Dexamethasone-tobramycin belongs to Anti Bacterial.
なぜ起こるのか
Additive tendon toxicity through impaired collagen turnover and tenocyte damage.
対処法
Avoid the combination in older patients or transplant recipients where possible. Stop ciprofloxacin and rest the limb if tendon pain or swelling appears.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CiprofloxacinとDexamethasone-tobramycinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Dexamethasone-tobramycinのその他の相互作用
Ciprofloxacinのその他の相互作用
よくある質問
Can I take Ciprofloxacin with Dexamethasone-tobramycin?
MediHelp rates the interaction as major. Ciprofloxacin and Dexamethasone-tobramycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fluoroquinolones and systemic corticosteroids together increase the risk of tendinopathy and tendon rupture, especially in older patients. Risk is greatest with systemic corticosteroid exposure.
How serious is the interaction between Ciprofloxacin and Dexamethasone-tobramycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in older patients or transplant recipients where possible. Stop ciprofloxacin and rest the limb if tendon pain or swelling appears.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Cisplatin. The full list is on the Dexamethasone-tobramycin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
