相互作用
Cefixime + Warfarin
重症度: 中等度
Cefixime and Warfarin: moderate interaction.
最終更新日
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概要
Cephalosporins can increase the anticoagulant effect of warfarin and raise INR in some patients, increasing the risk of bleeding. Infection itself, reduced food intake and antibiotic effects on gut flora also contribute to this change.
この相互作用をわかりやすく説明すると
Cefixime and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefixime belongs to Anti Bacterial; Warfarin belongs to Cardiovascular.
なぜ起こるのか
Probably reduced vitamin K availability from gut flora suppression, with the contribution of the acute illness; direct effect on warfarin metabolism is not established.
対処法
Check INR within a few days of starting cefixime and again during and after the course. Reduce the warfarin dose if INR rises and watch for bleeding.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CefiximeとWarfarinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Cefiximeのその他の相互作用
Warfarinのその他の相互作用
よくある質問
Can I take Cefixime with Warfarin?
MediHelp rates the interaction as moderate. Cefixime and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cephalosporins can increase the anticoagulant effect of warfarin and raise INR in some patients, increasing the risk of bleeding. Infection itself, reduced food intake and antibiotic effects on gut flora also contribute to this change.
How serious is the interaction between Cefixime and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check INR within a few days of starting cefixime and again during and after the course. Reduce the warfarin dose if INR rises and watch for bleeding.
What other medicines interact with Cefixime?
MediHelp also lists interactions of Cefixime with, for example, Typhoid vaccine live, Cholera vaccine, Kanamycin. The full list is on the Cefixime page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
