相互作用
Defibrotide + Warfarin
重症度: 併用禁忌
Defibrotide and Warfarin: contraindicated interaction.
最終更新日
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概要
Defibrotide enhances fibrinolysis and may add to the bleeding risk of warfarin. Its labeling contraindicates concomitant systemic anticoagulants. Serious hemorrhage may result.
この相互作用をわかりやすく説明すると
Defibrotide and Warfarin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Defibrotide belongs to Cardiovascular; Warfarin belongs to Cardiovascular.
なぜ起こるのか
Additive pharmacodynamic effects on hemostasis from vitamin K antagonism and defibrotide's profibrinolytic activity.
対処法
Do not co-administer; hold warfarin during defibrotide treatment. Check INR and reassess bleeding risk before restarting warfarin.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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アカウントを作成してPro+トライアルを始めると、DefibrotideとWarfarinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Warfarinのその他の相互作用
Defibrotideのその他の相互作用
よくある質問
Can I take Defibrotide with Warfarin?
MediHelp rates the interaction as contraindicated. Defibrotide and Warfarin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Defibrotide enhances fibrinolysis and may add to the bleeding risk of warfarin. Its labeling contraindicates concomitant systemic anticoagulants. Serious hemorrhage may result.
How serious is the interaction between Defibrotide and Warfarin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; hold warfarin during defibrotide treatment. Check INR and reassess bleeding risk before restarting warfarin.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Ketorolac, Abciximab, Acetylsalicylic acid. The full list is on the Warfarin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
