相互作用
Cefoxitin + Kanamycin
重症度: 中等度
Cefoxitin and Kanamycin: moderate interaction.
最終更新日
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概要
Giving a cephalosporin with an aminoglycoside may add to kidney injury, and aminoglycosides can also damage the inner ear. The risk is greatest in patients with existing renal impairment, older adults or those receiving prolonged courses.
この相互作用をわかりやすく説明すると
Cefoxitin and Kanamycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
なぜ起こるのか
Additive nephrotoxic potential, with aminoglycoside-related tubular injury and ototoxicity possibly aggravated by reduced renal clearance.
対処法
Monitor serum creatinine and urine output during combined therapy and check kanamycin levels where available. Adjust the aminoglycoside dose to renal function and report any hearing or balance symptoms promptly.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CefoxitinとKanamycinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Cefoxitinのその他の相互作用
よくある質問
Can I take Cefoxitin with Kanamycin?
MediHelp rates the interaction as moderate. Cefoxitin and Kanamycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Giving a cephalosporin with an aminoglycoside may add to kidney injury, and aminoglycosides can also damage the inner ear. The risk is greatest in patients with existing renal impairment, older adults or those receiving prolonged courses.
How serious is the interaction between Cefoxitin and Kanamycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and urine output during combined therapy and check kanamycin levels where available. Adjust the aminoglycoside dose to renal function and report any hearing or balance symptoms promptly.
What other medicines interact with Cefoxitin?
MediHelp also lists interactions of Cefoxitin with, for example, Amikacin, Aztreonam, Bcg vaccine live. The full list is on the Cefoxitin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
