相互作用
Cefoxitin + Chloramphenicol
重症度: 中等度
Cefoxitin and Chloramphenicol: moderate interaction.
最終更新日
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概要
Chloramphenicol is bacteriostatic and may reduce the bactericidal activity of beta-lactams such as cefoxitin in laboratory models. Clinical evidence of treatment failure is limited and mostly from older data in meningitis and severe infections. The concern is mainly for serious infections where rapid killing matters.
この相互作用をわかりやすく説明すると
Cefoxitin and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefoxitin belongs to Anti Bacterial; Chloramphenicol belongs to Anti Bacterial.
なぜ起こるのか
Pharmacodynamic antagonism: inhibition of bacterial protein synthesis by chloramphenicol may blunt the growth-dependent killing by beta-lactams.
対処法
Avoid combining them for serious infections where bactericidal activity is needed; if both are required, monitor clinical response closely.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CefoxitinとChloramphenicolの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Cefoxitinのその他の相互作用
Chloramphenicolのその他の相互作用
よくある質問
Can I take Cefoxitin with Chloramphenicol?
MediHelp rates the interaction as moderate. Cefoxitin and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol is bacteriostatic and may reduce the bactericidal activity of beta-lactams such as cefoxitin in laboratory models. Clinical evidence of treatment failure is limited and mostly from older data in meningitis and severe infections. The concern is mainly for serious infections where rapid killing matters.
How serious is the interaction between Cefoxitin and Chloramphenicol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining them for serious infections where bactericidal activity is needed; if both are required, monitor clinical response closely.
What other medicines interact with Cefoxitin?
MediHelp also lists interactions of Cefoxitin with, for example, Amikacin, Aztreonam, Bcg vaccine live. The full list is on the Cefoxitin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
