相互作用
Ceritinib + Vincristine
重症度: 重大
Ceritinib and Vincristine: major interaction.
最終更新日 出典: US FDA label
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概要
Ceritinib inhibits CYP3A4, which is the main route of vincristine metabolism. Higher vincristine exposure can worsen neurotoxicity, including severe peripheral neuropathy, constipation, and ileus.
この相互作用をわかりやすく説明すると
Ceritinib and Vincristine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ceritinib belongs to Oncology; Vincristine belongs to Oncology.
なぜ起こるのか
Ceritinib inhibits CYP3A4-mediated metabolism of vincristine, raising its plasma concentrations.
対処法
Avoid the combination if an alternative exists. If it is unavoidable, monitor closely for neuropathy and constipation and reduce the vincristine dose when toxicity appears.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、CeritinibとVincristineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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参考文献
Vincristineのその他の相互作用
Ceritinibのその他の相互作用
よくある質問
Can I take Ceritinib with Vincristine?
MediHelp rates the interaction as major. Ceritinib and Vincristine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ceritinib inhibits CYP3A4, which is the main route of vincristine metabolism. Higher vincristine exposure can worsen neurotoxicity, including severe peripheral neuropathy, constipation, and ileus.
How serious is the interaction between Ceritinib and Vincristine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if an alternative exists. If it is unavoidable, monitor closely for neuropathy and constipation and reduce the vincristine dose when toxicity appears.
What other medicines interact with Vincristine?
MediHelp also lists interactions of Vincristine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vincristine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
