相互作用
Atazanavir + Vincristine
重症度: 重大
Atazanavir and Vincristine: major interaction.
最終更新日 出典: US FDA label
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概要
Atazanavir inhibits CYP3A4 and may increase vincristine exposure, raising the risk of neurotoxicity and constipation or ileus. Toxicity is a concern with ritonavir- or cobicistat-boosted regimens in particular.
この相互作用をわかりやすく説明すると
Atazanavir and Vincristine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atazanavir belongs to Anti Virals; Vincristine belongs to Oncology.
なぜ起こるのか
Atazanavir inhibits CYP3A4, reducing vincristine clearance.
対処法
Monitor for neuropathy, constipation and myelosuppression, and consider an alternative antiretroviral without CYP3A inhibition. Reduce the vincristine dose if toxicity develops.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AtazanavirとVincristineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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参考文献
Vincristineのその他の相互作用
Atazanavirのその他の相互作用
よくある質問
Can I take Atazanavir with Vincristine?
MediHelp rates the interaction as major. Atazanavir and Vincristine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Atazanavir inhibits CYP3A4 and may increase vincristine exposure, raising the risk of neurotoxicity and constipation or ileus. Toxicity is a concern with ritonavir- or cobicistat-boosted regimens in particular.
How serious is the interaction between Atazanavir and Vincristine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neuropathy, constipation and myelosuppression, and consider an alternative antiretroviral without CYP3A inhibition. Reduce the vincristine dose if toxicity develops.
What other medicines interact with Vincristine?
MediHelp also lists interactions of Vincristine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Ceritinib. The full list is on the Vincristine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
