相互作用
Apalutamide + Vincristine
重症度: 重大
Apalutamide and Vincristine: major interaction.
最終更新日
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概要
Apalutamide may lower vincristine concentrations by inducing its metabolism. This could reduce antineoplastic efficacy, and the effect of a strong inducer on vinca alkaloids is well recognized with other agents.
この相互作用をわかりやすく説明すると
Apalutamide and Vincristine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apalutamide belongs to Endocrine; Vincristine belongs to Oncology.
なぜ起こるのか
Apalutamide induces CYP3A4, increasing the clearance of vincristine, a CYP3A4 substrate.
対処法
Avoid the combination or substitute an alternative agent where possible. If unavoidable, monitor for loss of therapeutic response.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ApalutamideとVincristineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Apalutamideのその他の相互作用
Vincristineのその他の相互作用
よくある質問
Can I take Apalutamide with Vincristine?
MediHelp rates the interaction as major. Apalutamide and Vincristine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apalutamide may lower vincristine concentrations by inducing its metabolism. This could reduce antineoplastic efficacy, and the effect of a strong inducer on vinca alkaloids is well recognized with other agents.
How serious is the interaction between Apalutamide and Vincristine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination or substitute an alternative agent where possible. If unavoidable, monitor for loss of therapeutic response.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
