相互作用
Chloramphenicol + Conivaptan
重症度: 重大
Chloramphenicol and Conivaptan: major interaction.
最終更新日
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概要
Chloramphenicol can inhibit CYP3A4 and may increase conivaptan concentrations, raising the risk of overly rapid sodium correction and osmotic demyelination. Conivaptan is contraindicated with strong CYP3A inhibitors, but chloramphenicol's inhibition is less well characterized.
この相互作用をわかりやすく説明すると
Chloramphenicol and Conivaptan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Inhibition of CYP3A4 by chloramphenicol decreases conivaptan metabolism.
対処法
Avoid the combination where possible; if used, monitor serum sodium frequently and watch for overcorrection.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ChloramphenicolとConivaptanの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Chloramphenicolのその他の相互作用
よくある質問
Can I take Chloramphenicol with Conivaptan?
MediHelp rates the interaction as major. Chloramphenicol and Conivaptan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Chloramphenicol can inhibit CYP3A4 and may increase conivaptan concentrations, raising the risk of overly rapid sodium correction and osmotic demyelination. Conivaptan is contraindicated with strong CYP3A inhibitors, but chloramphenicol's inhibition is less well characterized.
How serious is the interaction between Chloramphenicol and Conivaptan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if used, monitor serum sodium frequently and watch for overcorrection.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
