相互作用
Chloramphenicol + Tisotumab vedotin
重症度: 中等度
Chloramphenicol and Tisotumab vedotin: moderate interaction.
最終更新日
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概要
MMAE released from tisotumab vedotin is a CYP3A4 substrate, so chloramphenicol may increase exposure and toxicities such as neuropathy, ocular effects and neutropenia.
この相互作用をわかりやすく説明すると
Chloramphenicol and Tisotumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloramphenicol belongs to Anti Bacterial; Tisotumab vedotin belongs to Oncology.
なぜ起こるのか
CYP3A4 inhibition by chloramphenicol may reduce MMAE clearance.
対処法
Monitor for neuropathy, ocular toxicity and cytopenias. Prefer a non-inhibiting antibiotic where possible.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ChloramphenicolとTisotumab vedotinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Chloramphenicolのその他の相互作用
Tisotumab vedotinのその他の相互作用
よくある質問
Can I take Chloramphenicol with Tisotumab vedotin?
MediHelp rates the interaction as moderate. Chloramphenicol and Tisotumab vedotin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MMAE released from tisotumab vedotin is a CYP3A4 substrate, so chloramphenicol may increase exposure and toxicities such as neuropathy, ocular effects and neutropenia.
How serious is the interaction between Chloramphenicol and Tisotumab vedotin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neuropathy, ocular toxicity and cytopenias. Prefer a non-inhibiting antibiotic where possible.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
