相互作用
Chloroprocaine + Timolol
重症度: 中等度
Chloroprocaine and Timolol: moderate interaction.
最終更新日
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概要
If chloroprocaine is given with epinephrine, nonselective beta-blockade such as timolol can leave alpha-mediated pressor effects unopposed. This can produce hypertension with reflex bradycardia.
この相互作用をわかりやすく説明すると
Chloroprocaine and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloroprocaine belongs to Central Nervous System; Timolol belongs to Cardiovascular.
なぜ起こるのか
Timolol blocks beta-2 vasodilation, leaving epinephrine's alpha-mediated vasoconstriction unopposed.
対処法
Continue the beta-blocker perioperatively, use the lowest epinephrine dose or an epinephrine-free preparation, and monitor blood pressure and heart rate.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ChloroprocaineとTimololの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Timololのその他の相互作用
Chloroprocaineのその他の相互作用
よくある質問
Can I take Chloroprocaine with Timolol?
MediHelp rates the interaction as moderate. Chloroprocaine and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. If chloroprocaine is given with epinephrine, nonselective beta-blockade such as timolol can leave alpha-mediated pressor effects unopposed. This can produce hypertension with reflex bradycardia.
How serious is the interaction between Chloroprocaine and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Continue the beta-blocker perioperatively, use the lowest epinephrine dose or an epinephrine-free preparation, and monitor blood pressure and heart rate.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Albuterol, Aldesleukin. The full list is on the Timolol page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
