相互作用
Chlorpropamide + Insulin degludec-liraglutide
重症度: 重大
Chlorpropamide and Insulin degludec-liraglutide: major interaction.
最終更新日
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概要
Chlorpropamide, a long-acting sulfonylurea, combined with insulin and liraglutide substantially raises the risk of hypoglycemia, which can be severe and prolonged, especially in older adults or those with renal impairment.
この相互作用をわかりやすく説明すると
Chlorpropamide and Insulin degludec-liraglutide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chlorpropamide belongs to Endocrine; Insulin degludec-liraglutide belongs to Endocrine.
なぜ起こるのか
Additive glucose lowering from sulfonylurea-driven insulin secretion, exogenous insulin and glucose-dependent GLP-1 receptor stimulation.
対処法
Reduce the sulfonylurea dose, or preferably replace chlorpropamide with a safer agent, and monitor blood glucose closely. Educate patients on recognizing and treating hypoglycemia.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ChlorpropamideとInsulin degludec-liraglutideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Insulin degludec-liraglutideのその他の相互作用
Chlorpropamideのその他の相互作用
よくある質問
Can I take Chlorpropamide with Insulin degludec-liraglutide?
MediHelp rates the interaction as major. Chlorpropamide and Insulin degludec-liraglutide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Chlorpropamide, a long-acting sulfonylurea, combined with insulin and liraglutide substantially raises the risk of hypoglycemia, which can be severe and prolonged, especially in older adults or those with renal impairment.
How serious is the interaction between Chlorpropamide and Insulin degludec-liraglutide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the sulfonylurea dose, or preferably replace chlorpropamide with a safer agent, and monitor blood glucose closely. Educate patients on recognizing and treating hypoglycemia.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Clozapine, Diazoxide. The full list is on the Insulin degludec-liraglutide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
