相互作用
Chlorpropamide + Ofloxacin
重症度: 重大
Chlorpropamide and Ofloxacin: major interaction.
最終更新日
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概要
Ofloxacin can cause severe hypoglycemia or hyperglycemia in patients taking sulfonylureas. Chlorpropamide has a long half-life, so hypoglycemia may be prolonged and may need hospital treatment.
この相互作用をわかりやすく説明すると
Chlorpropamide and Ofloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chlorpropamide belongs to Endocrine; Ofloxacin belongs to Anti Bacterial.
なぜ起こるのか
Fluoroquinolones stimulate insulin release by blocking pancreatic beta-cell ATP-sensitive potassium channels, adding to the sulfonylurea effect.
対処法
Monitor blood glucose closely during ofloxacin therapy and consider reducing the sulfonylurea dose. Teach patients about hypoglycemia and use an alternative antibiotic in high-risk patients such as the elderly or those with renal impairment.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ChlorpropamideとOfloxacinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Ofloxacinのその他の相互作用
Chlorpropamideのその他の相互作用
よくある質問
Can I take Chlorpropamide with Ofloxacin?
MediHelp rates the interaction as major. Chlorpropamide and Ofloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ofloxacin can cause severe hypoglycemia or hyperglycemia in patients taking sulfonylureas. Chlorpropamide has a long half-life, so hypoglycemia may be prolonged and may need hospital treatment.
How serious is the interaction between Chlorpropamide and Ofloxacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during ofloxacin therapy and consider reducing the sulfonylurea dose. Teach patients about hypoglycemia and use an alternative antibiotic in high-risk patients such as the elderly or those with renal impairment.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
