相互作用
Chlorthalidone + Fosinopril-hydrochlorothiazide
重症度: 重大
Chlorthalidone and Fosinopril-hydrochlorothiazide: major interaction.
最終更新日
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概要
Chlorthalidone is a thiazide-like diuretic, so adding it to a regimen containing hydrochlorothiazide duplicates therapy. This increases the risk of hypokalemia, hyponatremia, hypomagnesemia, volume depletion and hyperuricemia with little added benefit.
この相互作用をわかりやすく説明すると
Chlorthalidone and Fosinopril-hydrochlorothiazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chlorthalidone belongs to Cardiovascular; Fosinopril-hydrochlorothiazide belongs to Cardiovascular.
なぜ起こるのか
Duplicate inhibition of the sodium-chloride cotransporter in the distal tubule causing additive diuresis and electrolyte loss.
対処法
Avoid using two thiazide-type diuretics together and keep a single agent. Check electrolytes and renal function if the overlap has occurred.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ChlorthalidoneとFosinopril-hydrochlorothiazideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Fosinopril-hydrochlorothiazideのその他の相互作用
- Aliskiren + Fosinopril-hydrochlorothiazide 併用禁忌
- Dofetilide + Fosinopril-hydrochlorothiazide 併用禁忌
- Fosinopril-hydrochlorothiazide + Protein a column 併用禁忌
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan 併用禁忌
- Aldesleukin + Fosinopril-hydrochlorothiazide 重大
- Amifostine + Fosinopril-hydrochlorothiazide 重大
Chlorthalidoneのその他の相互作用
よくある質問
Can I take Chlorthalidone with Fosinopril-hydrochlorothiazide?
MediHelp rates the interaction as major. Chlorthalidone and Fosinopril-hydrochlorothiazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Chlorthalidone is a thiazide-like diuretic, so adding it to a regimen containing hydrochlorothiazide duplicates therapy. This increases the risk of hypokalemia, hyponatremia, hypomagnesemia, volume depletion and hyperuricemia with little added benefit.
How serious is the interaction between Chlorthalidone and Fosinopril-hydrochlorothiazide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two thiazide-type diuretics together and keep a single agent. Check electrolytes and renal function if the overlap has occurred.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
