相互作用
Chlorthalidone + Digoxin
重症度: 重大
Chlorthalidone and Digoxin: major interaction.
最終更新日
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概要
Hypokalemia and hypomagnesemia induced by chlorthalidone sensitize the myocardium to digoxin and increase the risk of digoxin toxicity and arrhythmias. The risk is greater in elderly patients and those with renal impairment.
この相互作用をわかりやすく説明すると
Chlorthalidone and Digoxin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chlorthalidone belongs to Cardiovascular; Digoxin belongs to Cardiovascular.
なぜ起こるのか
Diuretic-induced potassium and magnesium depletion increases digoxin binding to Na+/K+-ATPase and enhances its proarrhythmic effects.
対処法
Monitor serum potassium and magnesium regularly and keep potassium in the normal range. Check digoxin level and ECG if symptoms of toxicity occur.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ChlorthalidoneとDigoxinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Chlorthalidoneのその他の相互作用
Digoxinのその他の相互作用
よくある質問
Can I take Chlorthalidone with Digoxin?
MediHelp rates the interaction as major. Chlorthalidone and Digoxin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Hypokalemia and hypomagnesemia induced by chlorthalidone sensitize the myocardium to digoxin and increase the risk of digoxin toxicity and arrhythmias. The risk is greater in elderly patients and those with renal impairment.
How serious is the interaction between Chlorthalidone and Digoxin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium regularly and keep potassium in the normal range. Check digoxin level and ECG if symptoms of toxicity occur.
What other medicines interact with Chlorthalidone?
MediHelp also lists interactions of Chlorthalidone with, for example, Amifostine, Atenolol-chlorthalidone, Candesartan-hydrochlorothiazide. The full list is on the Chlorthalidone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
