相互作用
Bosentan + Cholic acid
重症度: 重大
Bosentan and Cholic acid: major interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Bosentan inhibits the bile salt export pump, which can cause accumulation of bile salts in hepatocytes. Together with cholic acid, this may worsen liver injury.
この相互作用をわかりやすく説明すると
Bosentan and Cholic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bosentan belongs to Miscellaneous; Cholic acid belongs to Gastrointestinal Tract.
なぜ起こるのか
Bosentan inhibits BSEP, impairing biliary bile salt efflux.
対処法
Avoid the combination when possible; if used, monitor serum transaminases and bilirubin frequently and stop if liver injury develops.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BosentanとCholic acidの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Bosentanのその他の相互作用
Cholic acidのその他の相互作用
よくある質問
Can I take Bosentan with Cholic acid?
MediHelp rates the interaction as major. Bosentan and Cholic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bosentan inhibits the bile salt export pump, which can cause accumulation of bile salts in hepatocytes. Together with cholic acid, this may worsen liver injury.
How serious is the interaction between Bosentan and Cholic acid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when possible; if used, monitor serum transaminases and bilirubin frequently and stop if liver injury develops.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Cyclosporine, Glyburide. The full list is on the Bosentan page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
