相互作用
Cilostazol + Elvitegravir / cobicistat / emtricitabine / tenofovir df
重症度: 重大
Cilostazol and Elvitegravir / cobicistat / emtricitabine / tenofovir df: major interaction.
最終更新日
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概要
The cobicistat component strongly inhibits CYP3A4 and can substantially increase cilostazol exposure. This raises the risk of tachycardia, palpitations, headache and other dose-related adverse effects.
この相互作用をわかりやすく説明すると
Cilostazol and Elvitegravir / cobicistat / emtricitabine / tenofovir df can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Cobicistat inhibits CYP3A4-mediated cilostazol metabolism.
対処法
Reduce cilostazol to 50 mg twice daily, or choose an alternative agent. Monitor heart rate and cardiovascular symptoms.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CilostazolとElvitegravir / cobicistat / emtricitabine / tenofovir dfの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Cilostazolのその他の相互作用
よくある質問
Can I take Cilostazol with Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates the interaction as major. Cilostazol and Elvitegravir / cobicistat / emtricitabine / tenofovir df can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The cobicistat component strongly inhibits CYP3A4 and can substantially increase cilostazol exposure. This raises the risk of tachycardia, palpitations, headache and other dose-related adverse effects.
How serious is the interaction between Cilostazol and Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce cilostazol to 50 mg twice daily, or choose an alternative agent. Monitor heart rate and cardiovascular symptoms.
What other medicines interact with Cilostazol?
MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Anagrelide, Betrixaban. The full list is on the Cilostazol page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
