相互作用
Citalopram + Methylene blue
重症度: 併用禁忌
Citalopram and Methylene blue: contraindicated interaction.
最終更新日
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概要
Methylene blue inhibits MAO-A and, with SSRIs like citalopram, can cause severe serotonin syndrome. Reactions can include altered mental status, hyperthermia, seizures and neuromuscular abnormalities.
この相互作用をわかりやすく説明すると
Citalopram and Methylene blue are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
なぜ起こるのか
Reversible MAO-A inhibition by methylene blue added to SSRI-mediated serotonin reuptake blockade.
対処法
Avoid unless methylene blue is needed for an emergency; then stop citalopram and monitor for CNS toxicity. Resume only after the labeled interval after the last methylene blue dose.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、CitalopramとMethylene blueの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Citalopramのその他の相互作用
よくある質問
Can I take Citalopram with Methylene blue?
MediHelp rates the interaction as contraindicated. Citalopram and Methylene blue are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Methylene blue inhibits MAO-A and, with SSRIs like citalopram, can cause severe serotonin syndrome. Reactions can include altered mental status, hyperthermia, seizures and neuromuscular abnormalities.
How serious is the interaction between Citalopram and Methylene blue?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless methylene blue is needed for an emergency; then stop citalopram and monitor for CNS toxicity. Resume only after the labeled interval after the last methylene blue dose.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
