相互作用
Citalopram + Pimozide
重症度: 併用禁忌
Citalopram and Pimozide: contraindicated interaction.
最終更新日 出典: US FDA label
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概要
Both drugs prolong the QT interval, so combination raises the risk of torsades de pointes and sudden cardiac death. Pimozide labeling and citalopram labeling both caution against or contraindicate co-use with QT-prolonging drugs. Risk is greater at higher citalopram doses and in patients with electrolyte disturbance or cardiac disease.
この相互作用をわかりやすく説明すると
Citalopram and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Citalopram belongs to Central Nervous System; Pimozide belongs to Central Nervous System.
なぜ起こるのか
Additive QT prolongation. Citalopram is also partly metabolized by CYP2D6 and CYP3A4, and pimozide is a CYP2D6 and CYP3A4 substrate, so pharmacokinetic effects may add to this.
対処法
Do not co-administer. Choose an antidepressant with less QT effect, such as sertraline, and review the antipsychotic need.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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アカウントを作成してPro+トライアルを始めると、CitalopramとPimozideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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参考文献
Pimozideのその他の相互作用
Citalopramのその他の相互作用
よくある質問
Can I take Citalopram with Pimozide?
MediHelp rates the interaction as contraindicated. Citalopram and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs prolong the QT interval, so combination raises the risk of torsades de pointes and sudden cardiac death. Pimozide labeling and citalopram labeling both caution against or contraindicate co-use with QT-prolonging drugs. Risk is greater at higher citalopram doses and in patients with electrolyte disturbance or cardiac disease.
How serious is the interaction between Citalopram and Pimozide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Choose an antidepressant with less QT effect, such as sertraline, and review the antipsychotic need.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
