相互作用
Clarithromycin + Ponatinib
重症度: 重大
Clarithromycin and Ponatinib: major interaction.
最終更新日
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概要
Clarithromycin may markedly increase ponatinib concentrations, raising the risk of arterial occlusion, heart failure, hepatotoxicity and pancreatitis.
この相互作用をわかりやすく説明すると
Clarithromycin and Ponatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clarithromycin belongs to Anti Bacterial; Ponatinib belongs to Oncology.
なぜ起こるのか
Clarithromycin is a strong CYP3A4 inhibitor that reduces the metabolism of ponatinib.
対処法
Use a non-CYP3A4-inhibiting antibiotic where possible. If unavoidable, reduce the ponatinib dose as per labeling and monitor for cardiovascular and hepatic toxicity.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ClarithromycinとPonatinibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Clarithromycinのその他の相互作用
Ponatinibのその他の相互作用
よくある質問
Can I take Clarithromycin with Ponatinib?
MediHelp rates the interaction as major. Clarithromycin and Ponatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clarithromycin may markedly increase ponatinib concentrations, raising the risk of arterial occlusion, heart failure, hepatotoxicity and pancreatitis.
How serious is the interaction between Clarithromycin and Ponatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-CYP3A4-inhibiting antibiotic where possible. If unavoidable, reduce the ponatinib dose as per labeling and monitor for cardiovascular and hepatic toxicity.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
