相互作用
Chloramphenicol + Ponatinib
重症度: 重大
Chloramphenicol and Ponatinib: major interaction.
最終更新日
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概要
Ponatinib is metabolized by CYP3A4, so chloramphenicol may increase its levels. Higher exposure may raise the risk of serious toxicities including vascular occlusion, hypertension, pancreatitis and hepatotoxicity.
この相互作用をわかりやすく説明すると
Chloramphenicol and Ponatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chloramphenicol belongs to Anti Bacterial; Ponatinib belongs to Oncology.
なぜ起こるのか
Chloramphenicol inhibits CYP3A4 metabolism of ponatinib.
対処法
Use an alternative antibiotic. If unavoidable, reduce the ponatinib dose and monitor blood pressure, lipase and liver tests.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ChloramphenicolとPonatinibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Chloramphenicolのその他の相互作用
Ponatinibのその他の相互作用
よくある質問
Can I take Chloramphenicol with Ponatinib?
MediHelp rates the interaction as major. Chloramphenicol and Ponatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ponatinib is metabolized by CYP3A4, so chloramphenicol may increase its levels. Higher exposure may raise the risk of serious toxicities including vascular occlusion, hypertension, pancreatitis and hepatotoxicity.
How serious is the interaction between Chloramphenicol and Ponatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antibiotic. If unavoidable, reduce the ponatinib dose and monitor blood pressure, lipase and liver tests.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
