相互作用
Clopidogrel + Omeprazole
重症度: 重大
Clopidogrel and Omeprazole: major interaction.
最終更新日 出典: SPS (NHS), EMA SmPC, NCBI (US National Library of Medicine)
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概要
Omeprazole inhibits CYP2C19, reducing clopidogrel’s bioactivation and antiplatelet effect, which may increase risk of thrombotic/cardiovascular events.
この相互作用をわかりやすく説明すると
Clopidogrel and Omeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clopidogrel belongs to Cardiovascular; Omeprazole belongs to Gastrointestinal Tract.
なぜ起こるのか
CYP2C19 inhibition by omeprazole decreases formation of clopidogrel’s active metabolite → reduced platelet inhibition.
対処法
Avoid coadministration. Use an alternative acid suppressant (e.g., pantoprazole) or consider a non–CYP2C19-dependent P2Y12 inhibitor when appropriate.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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アカウントを作成してPro+トライアルを始めると、ClopidogrelとOmeprazoleの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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参考文献
Omeprazoleのその他の相互作用
Clopidogrelのその他の相互作用
よくある質問
Can I take Clopidogrel with Omeprazole?
MediHelp rates the interaction as major. Clopidogrel and Omeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Omeprazole inhibits CYP2C19, reducing clopidogrel’s bioactivation and antiplatelet effect, which may increase risk of thrombotic/cardiovascular events.
How serious is the interaction between Clopidogrel and Omeprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration. Use an alternative acid suppressant (e.g., pantoprazole) or consider a non–CYP2C19-dependent P2Y12 inhibitor when appropriate.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
