相互作用
Mavacamten + Omeprazole
重症度: 併用禁忌
Mavacamten and Omeprazole: contraindicated interaction.
最終更新日
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概要
Omeprazole inhibits CYP2C19 and can raise mavacamten exposure. Excess mavacamten can reduce left ventricular ejection fraction and cause heart failure from systolic dysfunction.
この相互作用をわかりやすく説明すると
Mavacamten and Omeprazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Mavacamten belongs to Cardiovascular; Omeprazole belongs to Gastrointestinal Tract.
なぜ起こるのか
Inhibition of CYP2C19-mediated metabolism of mavacamten increases its plasma concentrations.
対処法
Avoid the combination; use an acid suppressant without CYP2C19 inhibition (e.g., an H2 blocker, or per labeling) if required. If started or stopped, follow label guidance with echocardiographic monitoring of ejection fraction.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、MavacamtenとOmeprazoleの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Omeprazoleのその他の相互作用
Mavacamtenのその他の相互作用
よくある質問
Can I take Mavacamten with Omeprazole?
MediHelp rates the interaction as contraindicated. Mavacamten and Omeprazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Omeprazole inhibits CYP2C19 and can raise mavacamten exposure. Excess mavacamten can reduce left ventricular ejection fraction and cause heart failure from systolic dysfunction.
How serious is the interaction between Mavacamten and Omeprazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use an acid suppressant without CYP2C19 inhibition (e.g., an H2 blocker, or per labeling) if required. If started or stopped, follow label guidance with echocardiographic monitoring of ejection fraction.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Omeprazole page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
