相互作用
Clopidogrel + Selexipag
重症度: 中等度
Clopidogrel and Selexipag: moderate interaction.
最終更新日
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概要
Clopidogrel is a strong CYP2C8 inhibitor through its glucuronide metabolite, and selexipag and its active metabolite are CYP2C8 substrates. Exposure to the active metabolite of selexipag can increase markedly, raising the risk of prostacyclin-type adverse effects such as headache, diarrhea, nausea and jaw pain.
この相互作用をわかりやすく説明すると
Clopidogrel and Selexipag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clopidogrel belongs to Cardiovascular; Selexipag belongs to Cardiovascular.
なぜ起こるのか
Clopidogrel acyl-glucuronide inhibits CYP2C8, reducing metabolism of selexipag and its active metabolite.
対処法
Monitor for selexipag adverse effects and consider a reduced dosing frequency such as once daily if not tolerated, according to product labeling.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ClopidogrelとSelexipagの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Clopidogrelのその他の相互作用
Selexipagのその他の相互作用
よくある質問
Can I take Clopidogrel with Selexipag?
MediHelp rates the interaction as moderate. Clopidogrel and Selexipag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clopidogrel is a strong CYP2C8 inhibitor through its glucuronide metabolite, and selexipag and its active metabolite are CYP2C8 substrates. Exposure to the active metabolite of selexipag can increase markedly, raising the risk of prostacyclin-type adverse effects such as headache, diarrhea, nausea and jaw pain.
How serious is the interaction between Clopidogrel and Selexipag?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for selexipag adverse effects and consider a reduced dosing frequency such as once daily if not tolerated, according to product labeling.
What other medicines interact with Clopidogrel?
MediHelp also lists interactions of Clopidogrel with, for example, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Abrocitinib, Acetylsalicylic acid. The full list is on the Clopidogrel page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
