相互作用
Deferasirox + Selexipag
重症度: 中等度
Deferasirox and Selexipag: moderate interaction.
最終更新日
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概要
Selexipag is converted to its active metabolite partly through CYP2C8, and deferasirox inhibits CYP2C8 moderately. Exposure to the active metabolite may increase, leading to more prostacyclin-related adverse effects such as headache, diarrhea and jaw pain.
この相互作用をわかりやすく説明すると
Deferasirox and Selexipag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferasirox belongs to Miscellaneous; Selexipag belongs to Cardiovascular.
なぜ起こるのか
Deferasirox inhibits CYP2C8, reducing metabolism of selexipag and its active metabolite.
対処法
Reduce selexipag to once-daily dosing while deferasirox is used. Watch for adverse effects and return to the usual schedule if deferasirox is stopped.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DeferasiroxとSelexipagの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Deferasiroxのその他の相互作用
Selexipagのその他の相互作用
よくある質問
Can I take Deferasirox with Selexipag?
MediHelp rates the interaction as moderate. Deferasirox and Selexipag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selexipag is converted to its active metabolite partly through CYP2C8, and deferasirox inhibits CYP2C8 moderately. Exposure to the active metabolite may increase, leading to more prostacyclin-related adverse effects such as headache, diarrhea and jaw pain.
How serious is the interaction between Deferasirox and Selexipag?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce selexipag to once-daily dosing while deferasirox is used. Watch for adverse effects and return to the usual schedule if deferasirox is stopped.
What other medicines interact with Deferasirox?
MediHelp also lists interactions of Deferasirox with, for example, Acetylsalicylic acid, Alosetron, Aluminum hydroxide. The full list is on the Deferasirox page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
