相互作用
Gemfibrozil + Selexipag
重症度: 併用禁忌
Gemfibrozil and Selexipag: contraindicated interaction.
最終更新日
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概要
Gemfibrozil roughly doubles selexipag exposure and greatly increases exposure to its active metabolite. This raises the risk of prostacyclin-type adverse effects such as headache, hypotension, flushing, nausea and diarrhea.
この相互作用をわかりやすく説明すると
Gemfibrozil and Selexipag are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Gemfibrozil belongs to Cardiovascular; Selexipag belongs to Cardiovascular.
なぜ起こるのか
Gemfibrozil inhibits CYP2C8, which hydrolyzes/oxidizes selexipag and its active metabolite, reducing their clearance.
対処法
Avoid concomitant use; choose another lipid-lowering agent. Labeling contraindicates strong CYP2C8 inhibitors with selexipag.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、GemfibrozilとSelexipagの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Gemfibrozilのその他の相互作用
Selexipagのその他の相互作用
よくある質問
Can I take Gemfibrozil with Selexipag?
MediHelp rates the interaction as contraindicated. Gemfibrozil and Selexipag are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Gemfibrozil roughly doubles selexipag exposure and greatly increases exposure to its active metabolite. This raises the risk of prostacyclin-type adverse effects such as headache, hypotension, flushing, nausea and diarrhea.
How serious is the interaction between Gemfibrozil and Selexipag?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use; choose another lipid-lowering agent. Labeling contraindicates strong CYP2C8 inhibitors with selexipag.
What other medicines interact with Gemfibrozil?
MediHelp also lists interactions of Gemfibrozil with, for example, Daprodustat, Elagolix, Mavacamten. The full list is on the Gemfibrozil page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
