相互作用
Clozapine + Propylthiouracil
重症度: 重大
Clozapine and Propylthiouracil: major interaction.
最終更新日
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概要
Both drugs can cause agranulocytosis, and using them together may increase the risk of severe neutropenia and infection.
この相互作用をわかりやすく説明すると
Clozapine and Propylthiouracil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clozapine belongs to Central Nervous System; Propylthiouracil belongs to Endocrine.
なぜ起こるのか
Additive risk of bone marrow suppression and immune-mediated agranulocytosis.
対処法
Avoid the combination where possible and consider non-drug thyroid treatments. If used, monitor absolute neutrophil count closely and stop for neutropenia.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ClozapineとPropylthiouracilの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Clozapineのその他の相互作用
Propylthiouracilのその他の相互作用
よくある質問
Can I take Clozapine with Propylthiouracil?
MediHelp rates the interaction as major. Clozapine and Propylthiouracil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can cause agranulocytosis, and using them together may increase the risk of severe neutropenia and infection.
How serious is the interaction between Clozapine and Propylthiouracil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and consider non-drug thyroid treatments. If used, monitor absolute neutrophil count closely and stop for neutropenia.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
