相互作用
Methimazole + Propylthiouracil
重症度: 重大
Methimazole and Propylthiouracil: major interaction.
最終更新日
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概要
Both are thionamide antithyroid drugs with the same therapeutic action, so combining them offers no benefit. Each carries a risk of agranulocytosis, hepatotoxicity and other adverse effects, and duplication may add to this risk.
この相互作用をわかりやすく説明すると
Methimazole and Propylthiouracil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Methimazole belongs to Endocrine; Propylthiouracil belongs to Endocrine.
なぜ起こるのか
Therapeutic duplication with additive adverse effects, including myelosuppression, from two thionamides.
対処法
Avoid concurrent use; use a single thionamide and monitor blood counts and liver function, with prompt evaluation of fever or sore throat.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、MethimazoleとPropylthiouracilの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Propylthiouracilのその他の相互作用
Methimazoleのその他の相互作用
よくある質問
Can I take Methimazole with Propylthiouracil?
MediHelp rates the interaction as major. Methimazole and Propylthiouracil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are thionamide antithyroid drugs with the same therapeutic action, so combining them offers no benefit. Each carries a risk of agranulocytosis, hepatotoxicity and other adverse effects, and duplication may add to this risk.
How serious is the interaction between Methimazole and Propylthiouracil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; use a single thionamide and monitor blood counts and liver function, with prompt evaluation of fever or sore throat.
What other medicines interact with Propylthiouracil?
MediHelp also lists interactions of Propylthiouracil with, for example, Carbamazepine, Clozapine, Pexidartinib. The full list is on the Propylthiouracil page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
