相互作用
Clozapine + Thioridazine
重症度: 併用禁忌
Clozapine and Thioridazine: contraindicated interaction.
最終更新日
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概要
Thioridazine prolongs the QTc interval dose-dependently and is contraindicated with other QT-prolonging drugs, and clozapine can also lengthen the QTc interval. Together they raise the risk of torsades de pointes and sudden cardiac death.
この相互作用をわかりやすく説明すると
Clozapine and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Clozapine belongs to Central Nervous System; Thioridazine belongs to Central Nervous System.
なぜ起こるのか
Additive QTc prolongation (pharmacodynamic)
対処法
Do not co-administer; choose an alternative that does not prolong the QT interval.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ClozapineとThioridazineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Thioridazineのその他の相互作用
Clozapineのその他の相互作用
よくある質問
Can I take Clozapine with Thioridazine?
MediHelp rates the interaction as contraindicated. Clozapine and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Thioridazine prolongs the QTc interval dose-dependently and is contraindicated with other QT-prolonging drugs, and clozapine can also lengthen the QTc interval. Together they raise the risk of torsades de pointes and sudden cardiac death.
How serious is the interaction between Clozapine and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; choose an alternative that does not prolong the QT interval.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
