相互作用
Cobicistat + Lurasidone
重症度: 併用禁忌
Cobicistat and Lurasidone: contraindicated interaction.
最終更新日
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概要
Cobicistat is a strong CYP3A4 inhibitor that can greatly raise lurasidone exposure. This increases the risk of serious adverse effects, including extrapyramidal symptoms, sedation and QT effects, and lurasidone labeling contraindicates strong CYP3A4 inhibitors.
この相互作用をわかりやすく説明すると
Cobicistat and Lurasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cobicistat belongs to Miscellaneous; Lurasidone belongs to Central Nervous System.
なぜ起こるのか
Cobicistat strongly inhibits CYP3A4, markedly reducing lurasidone clearance.
対処法
Do not combine; choose an antipsychotic less dependent on CYP3A4 or an antiretroviral regimen without a booster.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、CobicistatとLurasidoneの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Lurasidoneのその他の相互作用
Cobicistatのその他の相互作用
よくある質問
Can I take Cobicistat with Lurasidone?
MediHelp rates the interaction as contraindicated. Cobicistat and Lurasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cobicistat is a strong CYP3A4 inhibitor that can greatly raise lurasidone exposure. This increases the risk of serious adverse effects, including extrapyramidal symptoms, sedation and QT effects, and lurasidone labeling contraindicates strong CYP3A4 inhibitors.
How serious is the interaction between Cobicistat and Lurasidone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; choose an antipsychotic less dependent on CYP3A4 or an antiretroviral regimen without a booster.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
