相互作用
Conivaptan + Lurasidone
重症度: 併用禁忌
Conivaptan and Lurasidone: contraindicated interaction.
最終更新日
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概要
Conivaptan is a potent CYP3A4 inhibitor and can markedly raise lurasidone exposure. Higher levels increase the risk of sedation, extrapyramidal symptoms, akathisia and other dose-related adverse effects. Lurasidone labeling contraindicates strong CYP3A4 inhibitors.
この相互作用をわかりやすく説明すると
Conivaptan and Lurasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
なぜ起こるのか
Inhibition of CYP3A4-mediated metabolism of lurasidone in the liver and gut wall.
対処法
Avoid the combination; if conivaptan is needed, consider an alternative antipsychotic or an alternative treatment for hyponatremia.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ConivaptanとLurasidoneの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Lurasidoneのその他の相互作用
よくある質問
Can I take Conivaptan with Lurasidone?
MediHelp rates the interaction as contraindicated. Conivaptan and Lurasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Conivaptan is a potent CYP3A4 inhibitor and can markedly raise lurasidone exposure. Higher levels increase the risk of sedation, extrapyramidal symptoms, akathisia and other dose-related adverse effects. Lurasidone labeling contraindicates strong CYP3A4 inhibitors.
How serious is the interaction between Conivaptan and Lurasidone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; if conivaptan is needed, consider an alternative antipsychotic or an alternative treatment for hyponatremia.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
