相互作用
Apalutamide + Lurasidone
重症度: 併用禁忌
Apalutamide and Lurasidone: contraindicated interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Apalutamide strongly induces CYP3A4 and markedly lowers lurasidone exposure, which can lead to loss of antipsychotic efficacy and relapse. Lurasidone labeling advises against use with strong CYP3A4 inducers.
この相互作用をわかりやすく説明すると
Apalutamide and Lurasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Apalutamide belongs to Endocrine; Lurasidone belongs to Central Nervous System.
なぜ起こるのか
Induction of CYP3A4 by apalutamide increases first-pass and systemic metabolism of lurasidone.
対処法
Do not combine; choose an antipsychotic that is not CYP3A4-dependent or an alternative antiandrogen. Induction persists for weeks after apalutamide is stopped.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ApalutamideとLurasidoneの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を7日間無料でお試し。カード登録不要。
Lurasidoneのその他の相互作用
Apalutamideのその他の相互作用
よくある質問
Can I take Apalutamide with Lurasidone?
MediHelp rates the interaction as contraindicated. Apalutamide and Lurasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Apalutamide strongly induces CYP3A4 and markedly lowers lurasidone exposure, which can lead to loss of antipsychotic efficacy and relapse. Lurasidone labeling advises against use with strong CYP3A4 inducers.
How serious is the interaction between Apalutamide and Lurasidone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; choose an antipsychotic that is not CYP3A4-dependent or an alternative antiandrogen. Induction persists for weeks after apalutamide is stopped.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Atazanavir, Carbamazepine, Clarithromycin. The full list is on the Lurasidone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
