相互作用
Cocaine + Dextroamphetamine
重症度: 重大
Cocaine and Dextroamphetamine: major interaction.
最終更新日
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概要
Both drugs increase synaptic monoamines and have sympathomimetic effects. Combined use can increase blood pressure and heart rate and the risk of arrhythmia, and systemic absorption from topical medical cocaine is limited but can be significant on mucosal surfaces. Illicit or high-dose cocaine use would carry a greater risk.
この相互作用をわかりやすく説明すると
Cocaine and Dextroamphetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cocaine belongs to Central Nervous System; Dextroamphetamine belongs to Central Nervous System.
なぜ起こるのか
Additive monoamine reuptake inhibition (cocaine) and release (amphetamine), producing sympathomimetic and serotonergic effects.
対処法
Avoid using cocaine in patients taking dextroamphetamine where alternative anesthetics exist. If it is used, monitor blood pressure, heart rate and ECG and limit the dose.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CocaineとDextroamphetamineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Dextroamphetamineのその他の相互作用
Cocaineのその他の相互作用
よくある質問
Can I take Cocaine with Dextroamphetamine?
MediHelp rates the interaction as major. Cocaine and Dextroamphetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs increase synaptic monoamines and have sympathomimetic effects. Combined use can increase blood pressure and heart rate and the risk of arrhythmia, and systemic absorption from topical medical cocaine is limited but can be significant on mucosal surfaces. Illicit or high-dose cocaine use would carry a greater risk.
How serious is the interaction between Cocaine and Dextroamphetamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using cocaine in patients taking dextroamphetamine where alternative anesthetics exist. If it is used, monitor blood pressure, heart rate and ECG and limit the dose.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
