相互作用
Cocaine + Procarbazine
重症度: 併用禁忌
Cocaine and Procarbazine: contraindicated interaction.
最終更新日
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概要
Cocaine blocks catecholamine and serotonin reuptake, and with an MAO inhibitor such as procarbazine there is risk of hypertensive crisis, arrhythmia and serotonin toxicity. Topical medical cocaine has limited absorption but the combination is still advised against.
この相互作用をわかりやすく説明すると
Cocaine and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cocaine belongs to Central Nervous System; Procarbazine belongs to Oncology.
なぜ起こるのか
MAO inhibition increases monoamine stores while cocaine blocks reuptake, producing additive sympathomimetic and serotonergic effects.
対処法
Avoid cocaine, including topical use, during and for 2 weeks after procarbazine. Use an alternative local anesthetic.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CocaineとProcarbazineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Procarbazineのその他の相互作用
Cocaineのその他の相互作用
よくある質問
Can I take Cocaine with Procarbazine?
MediHelp rates the interaction as contraindicated. Cocaine and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cocaine blocks catecholamine and serotonin reuptake, and with an MAO inhibitor such as procarbazine there is risk of hypertensive crisis, arrhythmia and serotonin toxicity. Topical medical cocaine has limited absorption but the combination is still advised against.
How serious is the interaction between Cocaine and Procarbazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid cocaine, including topical use, during and for 2 weeks after procarbazine. Use an alternative local anesthetic.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
