相互作用
Colistin + Polymyxin b
重症度: 併用禁忌
Colistin and Polymyxin b: contraindicated interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Colistin and polymyxin B are both polymyxins with similar toxicity, and combining them offers no benefit while sharply increasing the risk of kidney injury, neurotoxicity and neuromuscular blockade.
この相互作用をわかりやすく説明すると
Colistin and Polymyxin b are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Colistin belongs to Anti Bacterial; Polymyxin b belongs to Anti Bacterial.
なぜ起こるのか
Duplicate polymyxin therapy with additive nephrotoxic, neurotoxic and neuromuscular blocking effects.
対処法
Do not use together; choose one polymyxin. Monitor renal function and neurological status during therapy.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ColistinとPolymyxin bの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Colistinのその他の相互作用
Polymyxin bのその他の相互作用
よくある質問
Can I take Colistin with Polymyxin b?
MediHelp rates the interaction as contraindicated. Colistin and Polymyxin b are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Colistin and polymyxin B are both polymyxins with similar toxicity, and combining them offers no benefit while sharply increasing the risk of kidney injury, neurotoxicity and neuromuscular blockade.
How serious is the interaction between Colistin and Polymyxin b?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; choose one polymyxin. Monitor renal function and neurological status during therapy.
What other medicines interact with Colistin?
MediHelp also lists interactions of Colistin with, for example, Amikacin, Amphotericin b deoxycholate, Amphotericin b. The full list is on the Colistin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
