相互作用
Amphotericin b deoxycholate + Colistin
重症度: 重大
Amphotericin b deoxycholate and Colistin: major interaction.
最終更新日
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概要
Both drugs are nephrotoxic, and using them together increases the chance of acute kidney injury. Colistin also carries neurotoxic effects, and renal impairment raises its exposure further.
この相互作用をわかりやすく説明すると
Amphotericin b deoxycholate and Colistin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Additive direct tubular toxicity and renal vasoconstriction.
対処法
Avoid concurrent use if alternatives exist; otherwise monitor serum creatinine and electrolytes frequently, keep patients well hydrated and adjust colistin dose to renal function.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Amphotericin b deoxycholateとColistinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Colistinのその他の相互作用
よくある質問
Can I take Amphotericin b deoxycholate with Colistin?
MediHelp rates the interaction as major. Amphotericin b deoxycholate and Colistin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are nephrotoxic, and using them together increases the chance of acute kidney injury. Colistin also carries neurotoxic effects, and renal impairment raises its exposure further.
How serious is the interaction between Amphotericin b deoxycholate and Colistin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use if alternatives exist; otherwise monitor serum creatinine and electrolytes frequently, keep patients well hydrated and adjust colistin dose to renal function.
What other medicines interact with Colistin?
MediHelp also lists interactions of Colistin with, for example, Polymyxin b, Amikacin, Amphotericin b. The full list is on the Colistin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
