医薬品リファレンス
Exagamglogene autotemcel
Exagamglogene autotemcel is a medicine in the class miscellaneous. It is used for sickle cell disease.
- 薬効分類: Miscellaneous
- 効能・効果: sickle cell disease
最終更新日 出典: US FDA label
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
要点
- 薬効分類
- Miscellaneous
- ATCコード
- B06AX05
- 既知の相互作用
- 6 (重大: 4 · 中等度: 2)
- 商品名
- 1
- 国・市場
- 1
何に使われるか
作用のしくみ
Edited autologous CD34+ cells engraft in bone marrow and differentiate into erythroid cells with reduced BCL11A expression, increasing gamma-globin and HbF production. In SCD, HbF reduces intracellular HbS and red cell sickling; in TDT it improves globin imbalance and reduces transfusion dependence.
成人の通常用量（添付文書の要約）
SCD with recurrent VOCs or transfusion-dependent beta-thalassemia: minimum dose 3 × 10 6 CD34+ cells/kg, single one-time intravenous infusion; administer all vials, 48 hours to 7 days after the last myeloablative conditioning dose
妊娠と授乳
- 妊娠
- Unsafe No clinical or animal data. Must not be administered during pregnancy because of risks of myeloablative conditioning.
- 授乳
- Unsafe No data on milk presence or effects. Breastfeeding should be discontinued during conditioning because of myeloablative risks.
報告されている副作用
- Mucositis
- Febrile neutropenia
- Decreased appetite
- Neutropenia
- Thrombocytopenia
- Leukopenia
注意が必要な方
- Risk of neutrophil engraftment failure; monitor ANC and give rescue CD34+ cells if it occurs. G-CSF not recommended for 21 days after infusion.
- Delayed platelet engraftment with increased bleeding risk; monitor platelets frequently until recovery.
- Hypersensitivity including anaphylaxis can occur due to DMSO or dextran 40 in the cryopreservation solution.
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (6)
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、Exagamglogene autotemcelの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- How to give it
- Pharmacokinetics
- Patient counselling points
- IV preparation and dilution
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同じ分類のほかの薬剤
よくある質問
What is Exagamglogene autotemcel used for?
Exagamglogene autotemcel is a medicine in the class miscellaneous. It is used for Sickle cell disease, Thalassemia.
What side effects have been reported with Exagamglogene autotemcel?
Mucositis, Febrile neutropenia, Decreased appetite, Neutropenia, Thrombocytopenia, Leukopenia.
Can Exagamglogene autotemcel be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. No clinical or animal data. Must not be administered during pregnancy because of risks of myeloablative conditioning. Breastfeeding: Unsafe. No data on milk presence or effects. Breastfeeding should be discontinued during conditioning because of myeloablative risks.
What does Exagamglogene autotemcel interact with?
MediHelp lists 6 known interactions for Exagamglogene autotemcel. Major: 4 · Moderate: 2. The most serious include Deferasirox, Deferiprone, Deferoxamine.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
