相互作用
Cyclosporin + Danicopan
重症度: 中等度
Cyclosporin and Danicopan: moderate interaction.
最終更新日
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概要
Danicopan inhibits P-glycoprotein and may increase cyclosporine concentrations. This raises the risk of nephrotoxicity and other cyclosporine adverse effects.
この相互作用をわかりやすく説明すると
Cyclosporin and Danicopan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Danicopan belongs to Miscellaneous.
なぜ起こるのか
Danicopan inhibits intestinal P-glycoprotein, increasing cyclosporine absorption.
対処法
Monitor cyclosporine trough levels and renal function when starting or stopping danicopan, and reduce the cyclosporine dose if needed.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CyclosporinとDanicopanの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Cyclosporinのその他の相互作用
Danicopanのその他の相互作用
よくある質問
Can I take Cyclosporin with Danicopan?
MediHelp rates the interaction as moderate. Cyclosporin and Danicopan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danicopan inhibits P-glycoprotein and may increase cyclosporine concentrations. This raises the risk of nephrotoxicity and other cyclosporine adverse effects.
How serious is the interaction between Cyclosporin and Danicopan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels and renal function when starting or stopping danicopan, and reduce the cyclosporine dose if needed.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
