相互作用
Amiodarone + Danicopan
重症度: 中等度
Amiodarone and Danicopan: moderate interaction.
最終更新日
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概要
Danicopan inhibits P-gp and may increase exposure to amiodarone, a P-gp substrate. Higher amiodarone levels could increase bradycardia, QT prolongation and other toxicity.
この相互作用をわかりやすく説明すると
Amiodarone and Danicopan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Danicopan belongs to Miscellaneous.
なぜ起こるのか
Danicopan inhibits intestinal P-gp efflux, increasing amiodarone absorption.
対処法
Monitor ECG and heart rate, and consider reducing the amiodarone dose if toxicity appears.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmiodaroneとDanicopanの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Amiodaroneのその他の相互作用
Danicopanのその他の相互作用
よくある質問
Can I take Amiodarone with Danicopan?
MediHelp rates the interaction as moderate. Amiodarone and Danicopan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danicopan inhibits P-gp and may increase exposure to amiodarone, a P-gp substrate. Higher amiodarone levels could increase bradycardia, QT prolongation and other toxicity.
How serious is the interaction between Amiodarone and Danicopan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and heart rate, and consider reducing the amiodarone dose if toxicity appears.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
